{"id":437500,"date":"2023-02-22T09:04:00","date_gmt":"2023-02-22T08:04:00","guid":{"rendered":"https:\/\/innovationorigins.com\/?post_type=selected&p=437500"},"modified":"2023-02-22T09:04:00","modified_gmt":"2023-02-22T08:04:00","slug":"artificial-intelligence-and-infrared-imaging-can-automatically-classify-tumours","status":"publish","type":"selected","link":"https:\/\/ioplus.nl\/archive\/en\/selected\/artificial-intelligence-and-infrared-imaging-can-automatically-classify-tumours\/","title":{"rendered":"AI-driven infrared imaging facilitates colon cancer diagnostics"},"content":{"rendered":"\n

Artificial intelligence and infrared imaging can automatically classify tumours and are faster than previous methods. Scientists at Ruhr University Bochum have announced the successful emplyment of this technology in a press release<\/a>.<\/p>\n\n\n\n

The immense progress in the field of therapy options over the past years has significantly improved the chances of cure for patients with colon cancer. However, these new approaches, such as immunotherapies, require precise diagnosis so that they can be specifically tailored to the individual. Researchers at the Centre for Protein Diagnostics (PRODI) are using artificial intelligence in combination with infrared imaging to optimally tailor colon cancer therapy to individual patients. The label-free and automatable method can complement existing pathological analyses. The team led by Professor Klaus Gerwert reports in the \u201cEuropean Journal of Cancer\u201d in January 2023.<\/p>\n\n\n

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Fighting brain cancer with an implant and electrical stimulation\u00a0<\/div>
Many types of cancer have become increasingly treatable over the years. But sadly, the survival rate of the most aggressive type of brain cancer, glioblastoma, remains low. <\/div><\/div><\/div>\n\n\n

Deep insights into human tissue <\/h2>\n\n\n\n

The PRODI team has been developing a new digital imaging method over the last years. The so-called label-free infrared (IR) imaging measures the genomic and proteomic composition of the examined tissue, i.e. provides molecular information based on the infrared spectra. This information is decoded with the help of artificial intelligence and displayed as false-colour images. To do this, the researchers use image analysis methods from the field of deep learning.<\/p>\n\n\n\n

In cooperation with clinical partners, the PRODI team was able to show that the use of deep neural networks makes it possible to reliably determine the so-called microsatellite status, a prognostically and therapeutically relevant parameter, in colon cancer. In this process, the tissue sample goes through a standardised, user-independent, automated process and enables a spatially resolved differential classification of the tumour within one hour.<\/p>\n\n\n\n

Effectiveness of therapies<\/h2>\n\n\n\n

In classical diagnostics, microsatellite status (the amount of abnormalities) is determined either by complex immunostaining of various proteins or by DNA analysis. \u201c15 to 20 per cent of colon cancer patients show microsatellite instability in the tumour tissue,\u201d says Professor Andrea Tannapfel, head of the Institute of Pathology at Ruhr University. \u201cThis instability is a positive biomarker indicating that immunotherapy will be effective.\u201d<\/p>\n\n\n\n

With the ever-improving therapy options, the fast and uncomplicated determination of such biomarkers is also becoming more and more important. Based on IR microscopic data, neuronal networks were modified, optimised, and trained at PRODI to establish label-free diagnostics. Unlike immunostaining, this approach does not require dyes and is significantly faster than DNA analysis. \u201cWe were able to show that the accuracy of IR imaging for determining microsatellite status comes close to the most common method used in the clinic, immunostaining,\u201d says PhD student Stephanie Sch\u00f6rner. \u201cThrough constant further development and optimisation of the method, we expect a further increase in accuracy,\u201d adds Dr. Frederik Gro\u00dfer\u00fcschkamp.<\/p>\n","protected":false},"author":2583,"featured_media":493200,"template":"views\/single-selected.blade.php","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":""},"categories":[34665],"tags":[69735,10373,30764,4647,64871,71830,34074,4261],"location":[24456],"internal_archives":[],"class_list":["post-437500","selected","type-selected","status-publish","has-post-thumbnail","hentry","category-health","tag-ai-nl-3","tag-ai","tag-cancer-treatment","tag-health-en","tag-infrared","tag-kanker-2","tag-medicine","tag-research","location-germany"],"blocksy_meta":[],"acf":[],"featured_img":"https:\/\/ioplus.nl\/archive\/wp-content\/uploads\/2023\/01\/IMG_0738.jpg","coauthors":[],"author_meta":{"author_link":"https:\/\/ioplus.nl\/archive\/author\/francesco-morelli\/","display_name":"Francesco Morelli"},"relative_dates":{"created":"Posted 3 years ago","modified":"Updated 3 years ago"},"absolute_dates":{"created":"Posted on February 22, 2023","modified":"Updated on February 22, 2023"},"absolute_dates_time":{"created":"Posted on February 22, 2023 9:04 am","modified":"Updated on February 22, 2023 9:04 am"},"featured_img_caption":"","tax_additional":{"category":{"linked":["Health<\/a>"],"unlinked":["Health<\/span>"],"slug":"category","name":"Categories"},"post_tag":{"linked":["AI<\/a>","AI<\/a>","cancer treatment<\/a>","health<\/a>","infrared<\/a>","kanker<\/a>","medicine<\/a>","research<\/a>"],"unlinked":["AI<\/span>","AI<\/span>","cancer treatment<\/span>","health<\/span>","infrared<\/span>","kanker<\/span>","medicine<\/span>","research<\/span>"],"slug":"post_tag","name":"Tags"},"language":{"linked":["EN<\/a>"],"unlinked":["EN<\/span>"],"slug":"language","name":"Tags"},"post_translations":{"linked":["pll_63f5dbcb42484<\/a>"],"unlinked":["pll_63f5dbcb42484<\/span>"],"slug":"post_translations","name":""},"location":{"linked":["Germany<\/a>"],"unlinked":["Germany<\/span>"],"slug":"location","name":"Locations"},"internal_archives":{"linked":[],"unlinked":[],"slug":"internal_archives","name":"Internal Archives"}},"series_order":"","_links":{"self":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/selected\/437500","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/selected"}],"about":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/types\/selected"}],"author":[{"embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/users\/2583"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/media\/493200"}],"wp:attachment":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/media?parent=437500"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/categories?post=437500"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/tags?post=437500"},{"taxonomy":"location","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/location?post=437500"},{"taxonomy":"internal_archives","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/internal_archives?post=437500"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}