{"id":397682,"date":"2022-08-29T13:30:00","date_gmt":"2022-08-29T11:30:00","guid":{"rendered":"https:\/\/innovationorigins.com\/?post_type=selected&p=397682"},"modified":"2022-08-29T13:30:00","modified_gmt":"2022-08-29T11:30:00","slug":"blood-tests-can-detect-alzheimers-in-people-with-down-syndrome","status":"publish","type":"selected","link":"https:\/\/ioplus.nl\/archive\/en\/selected\/blood-tests-can-detect-alzheimers-in-people-with-down-syndrome\/","title":{"rendered":"Blood tests can detect Alzheimer’s in people with Down syndrome"},"content":{"rendered":"\n

Around 80 percent of people with Down syndrome develop Alzheimer\u2019s disease, often when they are between 40 and 50 years old. A study led by Lund University in Sweden has shown that a simple blood test can detect Alzheimer\u2019s disease in people with Down syndrome with a high degree of certainty. The findings are important for several reasons, not least the ability to make a correct diagnosis without invasive procedures. The study was recently published in JAMA Neurology, writes the Swedish university in a press release<\/a>.<\/p>\n\n\n\n

This is, so far, the only relatively large study in the world on Down syndrome in which a blood biomarker is compared with PET imaging results to see if people have the significant accumulations of the proteins in the brain that define Alzheimer\u2019s disease. The study involved 300 people with Down syndrome, 40 percent of whom showed signs of the onset of Alzheimer\u2019s disease.<\/p>\n\n\n\n

\u201cWith a simple blood test, we were able to detect both tau and amyloid pathologies, the disease-related changes in the brain that indicate whether a person has Alzheimer\u2019s or not, with over 90 percent certainty. We were even able to diagnose those who had not yet developed clear cognitive impairment due to Alzheimer\u2019s disease,\u201d says Oskar Hansson, professor of Neurology at Lund University and senior consultant at Sk\u00e5ne University Hospital.<\/p>\n\n\n\n

Leveraging the biomarker<\/h2>\n\n\n\n

In 2020, Oskar Hansson and his research colleagues announced their major breakthrough in Alzheimer\u2019s diagnostics: that a biomarker in the blood, phosphorylated tau (P-tau217) can detect Alzheimer\u2019s disease as early as 20 years before memory problems become apparent and, most importantly, distinguish Alzheimer\u2019s disease from other forms of dementia with about 95 percent accuracy. Clinical studies are now underway at 25 health centres in Sweden, that include both cognitive assessments and measurements of P-tau217 in blood.<\/p>\n\n\n\n

\u201cWe used the same blood biomarker in this study. Many people are unaware that Alzheimer\u2019s disease occurs much more frequently and at an earlier age in people with Down syndrome. It is also more complicated to diagnose Alzheimer\u2019s in a person with Down syndrome, as there is a pre-existing intellectual disability that makes it more difficult to detect cognitive impairment, and it requires the patient to agree to invasive procedures such as spinal fluid tests. It is therefore of particular importance that we find a simple diagnostic method,\u201d says Oskar Hansson.<\/p>\n\n\n

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<\/div><\/div>
Detecting Alzheimer’s up to 17 years in advance<\/div>
Alzheimer’s disease has a 15 to 20-year symptom-free course before the first clinical symptoms appear. Using an immuno-infrared sensor developed in Bochum, Germany, a research team has been able to identify signs of Alzheimer’s disease in the blood up to 17 years before the first clinical symptoms appear. <\/div><\/div><\/div>\n\n\n

Down people more prone to Alzheimer’s <\/h2>\n\n\n\n

The reason people with Down syndrome develop Alzheimer\u2019s disease at a comparatively high rate is that they have an extra chromosome, three copies of chromosome 21 instead of two. The gene for the amyloid precursor protein (APP) that is cleaved to produce amyloid, is located on chromosome 21.<\/p>\n\n\n\n

The study obtained both blood samples and PET scan results for people with Down syndrome, providing a unique opportunity to investigate whether the biomarker could also serve as a diagnostic marker for people with Down syndrome.<\/p>\n\n\n\n

\u201cOur results show that P-tau217 works just as well as a blood marker of Alzheimer\u2019s disease for persons with Down syndrome as it does for others and that other blood markers are not needed, Ptau217 is sufficient,” says\u00a0Shorena Janelidze, researcher at\u00a0Lund University.\u00a0The next step is to evaluate the performance of this biomarker in clinical practice and use it to improve clinical trials evaluating drugs targeting Alzheimer\u2019s disease in people with Down syndrome,\u201d concludes\u00a0Janelidze.<\/p>\n","protected":false},"author":2084,"featured_media":514786,"template":"","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":""},"categories":[34665],"tags":[29776,127278,128430,78995],"location":[54353],"internal_archives":[],"class_list":["post-397682","selected","type-selected","status-publish","has-post-thumbnail","hentry","category-health","tag-alzheimers-disease","tag-disease-detection","tag-down-syndrome","tag-lund-university","location-sweden"],"blocksy_meta":[],"acf":[],"featured_img":"https:\/\/ioplus.nl\/archive\/wp-content\/uploads\/2022\/04\/brain-1845962_1920.jpg","coauthors":[],"author_meta":{"author_link":"https:\/\/ioplus.nl\/archive\/author\/mauro-mereu\/","display_name":"Mauro Mereu"},"relative_dates":{"created":"Posted 4 years ago","modified":"Updated 4 years ago"},"absolute_dates":{"created":"Posted on August 29, 2022","modified":"Updated on August 29, 2022"},"absolute_dates_time":{"created":"Posted on August 29, 2022 1:30 pm","modified":"Updated on August 29, 2022 1:30 pm"},"featured_img_caption":"","tax_additional":{"category":{"linked":["Health<\/a>"],"unlinked":["Health<\/span>"],"slug":"category","name":"Categories"},"post_tag":{"linked":["Alzheimer's disease<\/a>","disease detection<\/a>","down syndrome<\/a>","Lund University<\/a>"],"unlinked":["Alzheimer's disease<\/span>","disease detection<\/span>","down syndrome<\/span>","Lund University<\/span>"],"slug":"post_tag","name":"Tags"},"language":{"linked":["EN<\/a>"],"unlinked":["EN<\/span>"],"slug":"language","name":"Tags"},"post_translations":{"linked":[],"unlinked":[],"slug":"post_translations","name":""},"location":{"linked":["Sweden<\/a>"],"unlinked":["Sweden<\/span>"],"slug":"location","name":"Locations"},"internal_archives":{"linked":[],"unlinked":[],"slug":"internal_archives","name":"Internal Archives"}},"series_order":"","_links":{"self":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/selected\/397682","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/selected"}],"about":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/types\/selected"}],"author":[{"embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/users\/2084"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/media\/514786"}],"wp:attachment":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/media?parent=397682"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/categories?post=397682"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/tags?post=397682"},{"taxonomy":"location","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/location?post=397682"},{"taxonomy":"internal_archives","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/internal_archives?post=397682"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}