{"id":388137,"date":"2022-07-22T10:00:00","date_gmt":"2022-07-22T08:00:00","guid":{"rendered":"https:\/\/innovationorigins.com\/?post_type=selected&p=388137"},"modified":"2022-07-22T10:00:00","modified_gmt":"2022-07-22T08:00:00","slug":"nanoscale-molecular-motor-unveiled","status":"publish","type":"selected","link":"https:\/\/ioplus.nl\/archive\/en\/selected\/nanoscale-molecular-motor-unveiled\/","title":{"rendered":"Nanoscale molecular motor unveiled"},"content":{"rendered":"\n

Be it in our cars, drills or the automatic coffee grinders \u2013 motors help us perform work in our everyday lives to accomplish a wide variety of tasks. On a much smaller scale, natural molecular motors perform vital tasks in our bodies. For instance, a motor protein known as ATP synthase produces the molecule adenosine triphosphate (ATP), which our body uses for short-term storage and transfer of energy, writes the Technical University of Munich in a press release<\/a>.<\/p>\n\n\n\n

While natural molecular motors are essential, it has been quite difficult to recreate motors on this scale with mechanical properties roughly similar to those of natural molecular motors like ATP synthase. A research team has now constructed a working nanoscale molecular rotary motor using the DNA origami method. The team was led by Hendrik Dietz<\/a>, Professor of Biomolecular Nanotechnology at TUM, Friedrich Simmel, Professor of Physics of Synthetic Biological Systems at TUM, and Ramin Golestanian, director at the Max Planck Institute for Dynamics and Self-Organization.<\/p>\n\n\n\n

A self-assembling nanomotor<\/h3>\n\n\n\n

The novel molecular motor consists of DNA \u2013 genetic material. The researchers used the DNA origami method to assemble the motor from DNA molecules. This method was invented by Paul Rothemund in 2006 and was later further developed by the research team at TUM. Several long single strands of DNA serve as a basis to which additional DNA strands attach themselves to as counterparts. The DNA sequences are selected in such a way that the attached strands and folds create the desired structures.<\/p>\n\n\n\n

“We\u2019ve been advancing this method of fabrication for many years and can now develop very precise and complex objects, such as molecular switches or hollow bodies that can trap viruses. If you put the DNA strands with the right sequences in solution, the objects self-assemble,\u201d says Dietz.<\/p>\n\n\n\n

The new nanomotor made of DNA material consists of three components: base, platform and rotor arm. The base is approximately 40 nanometers high and is fixed to a glass plate in solution via chemical bonds on a glass plate. A rotor arm of up to 500 nanometers in length is mounted on the base so that it can rotate. Another component is crucial for the motor to work as intended: a platform that lies between the base and the rotor arm. This platform contains obstacles that influence the movement of the rotor arm. To pass the obstacles and rotate, the rotor arm must bend upward a little, similar to a ratchet.<\/p>\n\n\n

<\/a>
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Targeted movement through AC voltage<\/h3>\n\n\n\n

Without energy supply, the rotor arms of the motors move randomly in one direction or the other, driven by random collisions with molecules from the surrounding solvent. However, as soon as AC voltage is applied via two electrodes, the rotor arms rotate in a targeted and continuous manner in one direction.<\/p>\n\n\n\n

\u201cThe new motor has unprecedented mechanical capabilities: It can achieve torques in the range of 10 piconewton times nanometer. And it can generate more energy per second than what\u2019s released when two ATP molecules are split,\u201d explains Ramin Golestanian, who led the theoretical analysis of the mechanism of the motor.<\/p>\n\n\n\n

Controlling speed and direction<\/h3>\n\n\n\n

The targeted movement of the motors results from a superposition of the fluctuating electrical forces with the forces experienced by the rotor arm due to the ratchet obstacles. The underlying mechanism realizes a so-called \u201cflashing Brownian ratchet\u201d. The researchers can control the speed and direction of the rotation via the direction of the electric field and also via the frequency and amplitude of the AC voltage.<\/p>\n\n\n\n

\u201cThe new motor could also have technical applications in the future. If we develop the motor further we could possibly use it in the future to drive user-defined chemical reactions, inspired by how ATP synthase makes ATP driven by rotation. Then, for example, surfaces could be densely coated with such motors. Then you would add starting materials, apply a little AC voltage and the motors produce the desired chemical compound,\u201d says Dietz.<\/p>\n","protected":false},"author":2084,"featured_media":512954,"template":"","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":""},"categories":[8553],"tags":[38911,5698,128188,24230],"location":[24456],"internal_archives":[],"class_list":["post-388137","selected","type-selected","status-publish","has-post-thumbnail","hentry","category-digital","tag-dna-en","tag-motor","tag-nanomotor","tag-tum","location-germany"],"blocksy_meta":[],"acf":[],"featured_img":"https:\/\/ioplus.nl\/archive\/wp-content\/uploads\/2022\/04\/o4hhMQjS-Nudgebox-scaled.jpg","coauthors":[],"author_meta":{"author_link":"https:\/\/ioplus.nl\/archive\/author\/mauro-mereu\/","display_name":"Mauro Mereu"},"relative_dates":{"created":"Posted 4 years ago","modified":"Updated 4 years ago"},"absolute_dates":{"created":"Posted on July 22, 2022","modified":"Updated on July 22, 2022"},"absolute_dates_time":{"created":"Posted on July 22, 2022 10:00 am","modified":"Updated on July 22, 2022 10:00 am"},"featured_img_caption":"","tax_additional":{"category":{"linked":["Digital<\/a>"],"unlinked":["Digital<\/span>"],"slug":"category","name":"Categories"},"post_tag":{"linked":["DNA<\/a>","motor<\/a>","nanomotor<\/a>","TUM<\/a>"],"unlinked":["DNA<\/span>","motor<\/span>","nanomotor<\/span>","TUM<\/span>"],"slug":"post_tag","name":"Tags"},"language":{"linked":["EN<\/a>"],"unlinked":["EN<\/span>"],"slug":"language","name":"Tags"},"post_translations":{"linked":["pll_62da4ebd30f30<\/a>"],"unlinked":["pll_62da4ebd30f30<\/span>"],"slug":"post_translations","name":""},"location":{"linked":["Germany<\/a>"],"unlinked":["Germany<\/span>"],"slug":"location","name":"Locations"},"internal_archives":{"linked":[],"unlinked":[],"slug":"internal_archives","name":"Internal Archives"}},"series_order":"","_links":{"self":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/selected\/388137","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/selected"}],"about":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/types\/selected"}],"author":[{"embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/users\/2084"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/media\/512954"}],"wp:attachment":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/media?parent=388137"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/categories?post=388137"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/tags?post=388137"},{"taxonomy":"location","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/location?post=388137"},{"taxonomy":"internal_archives","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/internal_archives?post=388137"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}