{"id":371375,"date":"2022-05-02T14:00:00","date_gmt":"2022-05-02T12:00:00","guid":{"rendered":"https:\/\/innovationorigins.com\/?post_type=selected&p=371375"},"modified":"2022-05-02T14:00:00","modified_gmt":"2022-05-02T12:00:00","slug":"medicine-for-reducing-fatty-acid-level-in-the-blood-is-on-the-way","status":"publish","type":"selected","link":"https:\/\/ioplus.nl\/archive\/en\/selected\/medicine-for-reducing-fatty-acid-level-in-the-blood-is-on-the-way\/","title":{"rendered":"Medicine for reducing fatty acid level in the blood is on the way"},"content":{"rendered":"\n

Many illnesses, such as type 2 diabetes, non-alcoholic fatty liver disease and heart problems are the result of an elevated level of fatty acids in the blood. Five years ago Graz researchers developed a drug treatment which reduces the level of fatty acids in a model organism. Now Robert Zimmermann (University of Graz) and Rolf Breinbauer (Graz University of Technology; TU Graz) are taking this research a step further. In a recently published paper they present a variation of the drug Atglistatin, which can now also be used in humans. This lays the foundation for the development of medications to treat lipid metabolism disorders such as type 2 diabetes, non-alcoholic fatty liver disease and heart failure, writes TU Graz in a press release<\/a>.<\/p>\n\n\n\n

A crucial enzyme<\/h3>\n\n\n\n

A key role in lipid metabolism is played by the enzyme ATGL (short for adipose triglyceride lipase). This mobilises fatty acids in the blood, which is the cause of many illnesses. \u201cSo the objective is to block ATGL in such a way that this suppression does not disrupt other processes in the body,\u201d explains Robert Zimmerman, describing this ingenious intervention in what is a highly sensitive system. He, Rolf Breinbauer and their teams spent five years working meticulously to refine an ATGL inhibitor which can be used in humans. The starting point was the agent Atglistatin which they had previously synthesised. Its molecular structure was adjusted until the optimal variation was found. This is called NG-497 and has been shown to deactivate human ATGL. Rolf Breinbauer verifies this: \u201cIn the cell culture model we are able to inhibit ATGL completely and have so far not seen any harmful side-effects of this intervention.\u201d<\/p>\n\n\n\n

Market-ready research<\/h3>\n\n\n\n

The research work was part of a programme by Research Studios Austria (RSA-Atglistatin), which was awarded funding of 1.2 million euros from the Austrian Research Promotion Agency (FFG). In the near future the\u00a0ATGL\u00a0inhibitors created by this team will be developed further as part of a wings4innovation project, and tested in preclinical studies for their effectiveness and any side-effects. As well as exemplifying the successful\u00a0collaboration between the University of Graz and Graz University of Technology<\/a>\u00a0in the natural sciences, this also demonstrates how university basic research can be of interest to high-tech pharma companies.<\/p>\n\n\n

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Diabetes medication effective against chronic heart failure<\/div>
Every year around 460,000 people are admitted to hospital for chronic heart failure just in Germany.<\/div><\/div><\/div>","protected":false},"author":2084,"featured_media":519016,"template":"","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":""},"categories":[34665],"tags":[26034,37420,127552,31696,127544],"location":[28214],"internal_archives":[],"class_list":["post-371375","selected","type-selected","status-publish","has-post-thumbnail","hentry","category-health","tag-blood","tag-diabetes-en","tag-fatty-acid","tag-tu-graz-en","tag-uni-graz","location-austria"],"blocksy_meta":[],"acf":[],"featured_img":"https:\/\/ioplus.nl\/archive\/wp-content\/uploads\/2020\/09\/pulse-trace-163708_1280.jpg","coauthors":[],"author_meta":{"author_link":"https:\/\/ioplus.nl\/archive\/author\/mauro-mereu\/","display_name":"Mauro Mereu"},"relative_dates":{"created":"Posted 4 years ago","modified":"Updated 4 years ago"},"absolute_dates":{"created":"Posted on May 2, 2022","modified":"Updated on May 2, 2022"},"absolute_dates_time":{"created":"Posted on May 2, 2022 2:00 pm","modified":"Updated on May 2, 2022 2:00 pm"},"featured_img_caption":"","tax_additional":{"category":{"linked":["Health<\/a>"],"unlinked":["Health<\/span>"],"slug":"category","name":"Categories"},"post_tag":{"linked":["blood<\/a>","Diabetes<\/a>","fatty acid<\/a>","TU Graz<\/a>","Uni Graz<\/a>"],"unlinked":["blood<\/span>","Diabetes<\/span>","fatty acid<\/span>","TU Graz<\/span>","Uni Graz<\/span>"],"slug":"post_tag","name":"Tags"},"language":{"linked":["EN<\/a>"],"unlinked":["EN<\/span>"],"slug":"language","name":"Tags"},"post_translations":{"linked":["pll_626fc6c4a1dac<\/a>"],"unlinked":["pll_626fc6c4a1dac<\/span>"],"slug":"post_translations","name":""},"location":{"linked":["Austria<\/a>"],"unlinked":["Austria<\/span>"],"slug":"location","name":"Locations"},"internal_archives":{"linked":[],"unlinked":[],"slug":"internal_archives","name":"Internal Archives"}},"series_order":"","_links":{"self":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/selected\/371375","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/selected"}],"about":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/types\/selected"}],"author":[{"embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/users\/2084"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/media\/519016"}],"wp:attachment":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/media?parent=371375"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/categories?post=371375"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/tags?post=371375"},{"taxonomy":"location","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/location?post=371375"},{"taxonomy":"internal_archives","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/internal_archives?post=371375"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}