{"id":268982,"date":"2021-01-18T17:00:07","date_gmt":"2021-01-18T16:00:07","guid":{"rendered":"http:\/\/innovationorigins.com\/?p=268982"},"modified":"2021-01-18T17:00:07","modified_gmt":"2021-01-18T16:00:07","slug":"using-electrically-charged-nanoparticles-to-fight-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/ioplus.nl\/archive\/en\/using-electrically-charged-nanoparticles-to-fight-parkinsons-disease\/","title":{"rendered":"Using electrically charged nanoparticles to fight Parkinson&#8217;s disease"},"content":{"rendered":"\n<p id=\"block-0a175538-cbed-4693-a1e5-b165c1b3579a\">More than six million people worldwide suffer from Parkinson&#8217;s Disease. It is a disease that is often treated with what is known as &#8220;deep brain stimulation,&#8221; whereby a patient has centimeter-long electrodes implanted into their brain that stimulate certain areas.<\/p>\n\n\n\n<p id=\"block-9b97f46c-0df1-4479-b420-c55b87da2cd3\">It is a technique that is improving all the time, but it also has disadvantages. One of those disadvantages is that it involves fairly major surgery. A second disadvantage is that a patient has to undergo surgery not just one time but several times. This is because the electrical stimulator is connected to a battery that must be replaced every 3 to 5 years.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"block-2de2e1d0-6cf4-40fe-a48f-a5e2b5347093\">50 nanometers<\/h3>\n\n\n\n<p id=\"block-dbd8f68d-0c6f-41ed-a1cb-24b8519b6381\">Which is why scientists from <a href=\"https:\/\/www.mumc.nl\/actueel\/nieuws\/wetenschappelijke-doorbraak-magnetische-diepe-hersenstimulatie\">Maastricht UMC+<\/a> (The Netherlands), the <a href=\"https:\/\/www.mpg.de\/16291014\/parkinson-nanopartikel?c=2191\">Max-Planck Institute for Intelligent Systems<\/a> and the <a href=\"https:\/\/www.kit.edu\/kit\/english\/index.php\">Karlsruher Institute of Technology <\/a>(KIT, both in Germany) figured out a different method that entails electrically charged nanoparticles being inserted into the brain instead. At just 50 nanometers in size, these nanoparticles are a thousand times smaller than a human hair. Once inserted into the brain, they can wirelessly stimulate the affected areas via a magnetic field.<\/p>\n\n\n\n<p id=\"block-4f285029-9547-419a-b0dc-92e06eab393b\">Preliminary tests in mice have gone well, according to the researchers. The results of the study were published in the academic journal <a rel=\"noreferrer noopener\" href=\"https:\/\/advances.sciencemag.org\/content\/7\/3\/eabc4189\" target=\"_blank\">Science Advances<\/a>.<\/p>\n\n\n\n<p id=\"block-40c4a499-a1c0-46d1-a1e5-47fda2fabe0a\">As part of the research, the nanoparticles were first studied in human nerve cells in a laboratory, the Maastricht UMC+ reports. There it was seen that an external magnetic field causes the cells to become electrically activated.<\/p>\n\n\n\n<figure class=\"wp-block-image\" id=\"block-040857b9-019d-4162-8e12-b0bc771bee35\"><img decoding=\"async\" src=\"https:\/\/archive.ioplus.nl\/wp-content\/uploads\/2021\/01\/original-1-678x452.jpeg\" alt=\"This image has an empty alt attribute; its file name is original-1-678x452.jpeg\"\/><figcaption>The classical way of deep brain stimulation with electrodes, Photo Max-Planck Institute<\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"block-381eaeca-19bb-43f1-8996-e99448272b2e\">Mice on the catwalk<\/h3>\n\n\n\n<p id=\"block-e00566b5-940c-4a23-965b-34d516054ae7\">The next step was then carried out on mice. The nanoparticles were inserted into a site where classical deep brain stimulation (via surgery) is also known to be effective. With the help of various experiments, it was demonstrated that applying a magnetic field on that area also ensures that brain areas can be stimulated wirelessly.<\/p>\n\n\n\n<p id=\"block-5128c0f4-03a8-44e5-b7f6-46975b94c9f9\">Even the movement behavior of the mice was affected by the magnetic stimulation when compared to the mice that were used in the control group. They ran faster on the &#8220;catwalk.&#8221;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"block-42ea1a3a-77b0-42c0-a29d-6fe3dee18b60\">Revolution<\/h3>\n\n\n\n<p id=\"block-f2b6b0d0-178a-422e-a66b-277371a741a1\">&#8220;This is a major breakthrough in the field of deep brain stimulation,&#8221; says Ali Jahanshahi, one of the researchers at Maastricht UMC+. &#8220;In future research, we intend to further study the possibilities and limitations of this new technology.&#8221; Jahanshahi recently received a grant from the Dutch Research Council (NWO) to carry out the research.<\/p>\n\n\n\n<p id=\"block-894bed6c-285c-4c47-a712-e7ebb1f3ccb9\">Even though the application of magnetic brain stimulation with nanoparticles in humans may still be a long way off, its potential is very promising, says Maastricht neurosurgeon Yasin Temel: &#8220;If we can help patients with severe brain disease without the need for lengthy surgery and repeated battery replacement, that would, of course, be fantastic.&#8221;<\/p>\n\n\n\n<p id=\"block-07bc9c4f-15e6-4991-9a0e-563800d1b605\">Metin Sitti, head of department at the Max Planck Institute for Intelligent Systems, is also enthusiastic: &#8220;Wireless medical devices can revolutionize medicine in the future with minimally invasive, implantable, local and effective treatment of a lot of diseases. This study is a first step in the right direction.&#8221;<\/p>\n\n\n\n<p id=\"block-08379c43-4fec-491a-94d5-6cb53eeb3607\"><em><strong>See our other articles on Parkinson&#8217;s research <a href=\"https:\/\/innovationorigins.com\/?s=parkinson%27s\">here<\/a>.<\/strong> <\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>More than six million people worldwide suffer from Parkinson&#8217;s Disease. It is a disease that is often treated with what is known as &#8220;deep brain stimulation,&#8221; whereby a patient has centimeter-long electrodes implanted into their brain that stimulate certain areas. It is a technique that is improving all the time, but it also has disadvantages. [&hellip;]<\/p>\n","protected":false},"author":1723,"featured_media":523546,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[34665],"tags":[57688,56752,33393,31405,27288,42362,48500,57690,57692,38762,27509,40808],"location":[6763],"article_type":[],"serie":[],"archives":[],"internal_archives":[],"reboot-archive":[],"class_list":["post-268982","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","tag-brain-implants","tag-brain-surgery","tag-deep-brain-stimulation","tag-kit-en","tag-maastricht-umc","tag-max-planck-institute-for-intelligent-systems","tag-nanoparticles","tag-neuro-implants","tag-neurological-research","tag-neurology","tag-newsletter-en","tag-parkinsons-disease","location-netherlands"],"blocksy_meta":[],"acf":{"subtitle":"The Dutch university medical center at Maastricht UMC+ and the German Max-Planck and KIT institutes have announced a scientific breakthrough in magnetic deep brain stimulation.","text_display_homepage":false},"author_meta":{"display_name":"Maurits Kuypers","author_link":"https:\/\/ioplus.nl\/archive\/author\/maurits-kuypers\/"},"featured_img":"https:\/\/ioplus.nl\/archive\/wp-content\/uploads\/2021\/01\/original-300x214.jpeg","coauthors":[],"tax_additional":{"categories":{"linked":["<a href=\"https:\/\/ioplus.nl\/archive\/en\/category\/health\/\" class=\"advgb-post-tax-term\">Health<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Health<\/span>"]},"tags":{"linked":["<a href=\"https:\/\/ioplus.nl\/archive\/en\/category\/health\/\" class=\"advgb-post-tax-term\">brain implants<\/a>","<a href=\"https:\/\/ioplus.nl\/archive\/en\/category\/health\/\" class=\"advgb-post-tax-term\">brain surgery<\/a>","<a href=\"https:\/\/ioplus.nl\/archive\/en\/category\/health\/\" class=\"advgb-post-tax-term\">deep brain stimulation<\/a>","<a href=\"https:\/\/ioplus.nl\/archive\/en\/category\/health\/\" class=\"advgb-post-tax-term\">KIT<\/a>","<a href=\"https:\/\/ioplus.nl\/archive\/en\/category\/health\/\" class=\"advgb-post-tax-term\">Maastricht UMC+<\/a>","<a href=\"https:\/\/ioplus.nl\/archive\/en\/category\/health\/\" class=\"advgb-post-tax-term\">Max Planck Institute for Intelligent Systems<\/a>","<a href=\"https:\/\/ioplus.nl\/archive\/en\/category\/health\/\" class=\"advgb-post-tax-term\">nanoparticles<\/a>","<a href=\"https:\/\/ioplus.nl\/archive\/en\/category\/health\/\" class=\"advgb-post-tax-term\">neuro-implants<\/a>","<a href=\"https:\/\/ioplus.nl\/archive\/en\/category\/health\/\" class=\"advgb-post-tax-term\">neurological research<\/a>","<a href=\"https:\/\/ioplus.nl\/archive\/en\/category\/health\/\" class=\"advgb-post-tax-term\">neurology<\/a>","<a href=\"https:\/\/ioplus.nl\/archive\/en\/category\/health\/\" class=\"advgb-post-tax-term\">Newsletter<\/a>","<a href=\"https:\/\/ioplus.nl\/archive\/en\/category\/health\/\" class=\"advgb-post-tax-term\">Parkinson&#039;s disease<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">brain implants<\/span>","<span class=\"advgb-post-tax-term\">brain surgery<\/span>","<span class=\"advgb-post-tax-term\">deep brain stimulation<\/span>","<span class=\"advgb-post-tax-term\">KIT<\/span>","<span class=\"advgb-post-tax-term\">Maastricht UMC+<\/span>","<span class=\"advgb-post-tax-term\">Max Planck Institute for Intelligent Systems<\/span>","<span class=\"advgb-post-tax-term\">nanoparticles<\/span>","<span class=\"advgb-post-tax-term\">neuro-implants<\/span>","<span class=\"advgb-post-tax-term\">neurological research<\/span>","<span class=\"advgb-post-tax-term\">neurology<\/span>","<span class=\"advgb-post-tax-term\">Newsletter<\/span>","<span class=\"advgb-post-tax-term\">Parkinson&#039;s disease<\/span>"]}},"comment_count":"0","relative_dates":{"created":"Posted 5 years ago","modified":"Updated 5 years ago"},"absolute_dates":{"created":"Posted on January 18, 2021","modified":"Updated on January 18, 2021"},"absolute_dates_time":{"created":"Posted on January 18, 2021 5:00 pm","modified":"Updated on January 18, 2021 5:00 pm"},"featured_img_caption":"","series_order":"","_links":{"self":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/posts\/268982","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/users\/1723"}],"replies":[{"embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/comments?post=268982"}],"version-history":[{"count":0,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/posts\/268982\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/media\/523546"}],"wp:attachment":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/media?parent=268982"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/categories?post=268982"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/tags?post=268982"},{"taxonomy":"location","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/location?post=268982"},{"taxonomy":"article_type","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/article_type?post=268982"},{"taxonomy":"serie","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/serie?post=268982"},{"taxonomy":"archives","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/archives?post=268982"},{"taxonomy":"internal_archives","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/internal_archives?post=268982"},{"taxonomy":"reboot-archive","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/reboot-archive?post=268982"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}