{"id":258340,"date":"2020-11-24T09:00:00","date_gmt":"2020-11-24T08:00:00","guid":{"rendered":"http:\/\/innovationorigins.com\/?p=258340"},"modified":"2020-11-24T09:00:00","modified_gmt":"2020-11-24T08:00:00","slug":"influenza-drug-prevents-sars-cov-2-from-invading-host-cells","status":"publish","type":"post","link":"https:\/\/ioplus.nl\/archive\/en\/influenza-drug-prevents-sars-cov-2-from-invading-host-cells\/","title":{"rendered":"Influenza drug prevents SARS-CoV-2 from invading host cells"},"content":{"rendered":"\n

The corona pandemic<\/strong> is still raging around the globe. And it is still causing record numbers of infections and disease-related deaths on a daily basis. At the same time, there are new glimmers of hope almost every day that this state of emergency will come to an end in the foreseeable future. The development of vaccines is making leaps and bounds. Biontech\/Pfizer,<\/strong> Moderna<\/strong>, and now also AstraZeneca <\/strong>are close to obtaining approval for their products. But there is also a constant stream of new insights when it comes to drugs for treating COVID-19<\/strong>, the disease caused by the coronavirus.<\/p>\n\n\n\n

Scientists at the Goethe-Universit\u00e4t Frankfurt am Main<\/strong><\/a> in Germany, the University of Kent<\/strong><\/a> (UK), and the Medizinische Hochschule Hannover<\/a> (Germany) have now discovered that the protease inhibitor<\/strong> aprotinin<\/strong> can prevent cells from becoming infected. In the past, aprotinin <\/strong>was used to treat post-operative bleeding. Nowadays, doctors in Russia use it to treat influenza.<\/p>\n\n\n\n

Spikes become inactive<\/strong><\/h3>\n\n\n\n

The SARS-CoV-2 virus <\/strong>is covered in spike proteins on its surface. It uses these spikes to dock to proteins (ACE2 receptors<\/strong>) on the surface of host cells. However, before this can be done, parts of the spike protein must be separated by the enzymes of the host cells – proteases<\/strong>.

Under the supervision of Prof. Jindrich Cinatl, Institute of Medical Virology<\/strong> at Frankfurt University Hospital,<\/strong> and Prof. Martin Michaelis and Dr. Mark Wess (both from the University of Kent), researchers have now been able to demonstrate in experiments with different cell cultures that aprotinin<\/strong> can stop virus replication in the cells. The scientists explain that since SARS-CoV-2 reduces the formation of protease inhibitors by the host cells after infection, aprotinin is apparently able to compensate for this. The virus can no longer penetrate the host cells.

\u201cOur findings show that aprotinin is effective against SARS-CoV2 in concentrations that can be achieved in patients,\u201c Professor Jindrich Cinatl “In aprotinin we have a drug candidate for the treatment of COVID-19 that is already approved for other indications and could readily be tested in patients.\u201d

In Russia, aprotinin aerosols for the treatment of influenza have already been approved, given that these types of influenza viruses also need host cell proteases in order to penetrate cells.<\/p>\n","protected":false},"excerpt":{"rendered":"

The corona pandemic is still raging around the globe. And it is still causing record numbers of infections and disease-related deaths on a daily basis. At the same time, there are new glimmers of hope almost every day that this state of emergency will come to an end in the foreseeable future. The development of […]<\/p>\n","protected":false},"author":1660,"featured_media":258315,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[34665],"tags":[56019,56021,56023,37802,27509,48131,52285,56017],"location":[24456],"article_type":[],"serie":[],"archives":[],"internal_archives":[],"reboot-archive":[],"class_list":["post-258340","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","tag-aprotinin","tag-frankfurt-university-hospital","tag-goethe-universitat-frankfurt-am-main","tag-medizinische-hochschule-hannover","tag-newsletter-en","tag-sars-cov-2","tag-sars-cov-2-virus","tag-university-of-kent","location-germany"],"blocksy_meta":[],"acf":{"subtitle":"German and British scientists have discovered that the protease inhibitor aprotinin can prevent the SARS CoV-2 virus from entering host cells.","text_display_homepage":false},"author_meta":{"display_name":"Petra Wiesmayer","author_link":"https:\/\/ioplus.nl\/archive\/author\/petra-wiesmayer\/"},"featured_img":null,"coauthors":[],"tax_additional":{"categories":{"linked":["Health<\/a>"],"unlinked":["Health<\/span>"]},"tags":{"linked":["aprotinin<\/a>","Frankfurt University Hospital<\/a>","Goethe-Universit\u00e4t Frankfurt am Main<\/a>","Medizinische Hochschule Hannover<\/a>","Newsletter<\/a>","SARS-CoV-2<\/a>","SARS-CoV-2 virus<\/a>","University of Kent<\/a>"],"unlinked":["aprotinin<\/span>","Frankfurt University Hospital<\/span>","Goethe-Universit\u00e4t Frankfurt am Main<\/span>","Medizinische Hochschule Hannover<\/span>","Newsletter<\/span>","SARS-CoV-2<\/span>","SARS-CoV-2 virus<\/span>","University of Kent<\/span>"]}},"comment_count":"0","relative_dates":{"created":"Posted 5 years ago","modified":"Updated 5 years ago"},"absolute_dates":{"created":"Posted on November 24, 2020","modified":"Updated on November 24, 2020"},"absolute_dates_time":{"created":"Posted on November 24, 2020 9:00 am","modified":"Updated on November 24, 2020 9:00 am"},"featured_img_caption":"","series_order":"","_links":{"self":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/posts\/258340","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/users\/1660"}],"replies":[{"embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/comments?post=258340"}],"version-history":[{"count":0,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/posts\/258340\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/"}],"wp:attachment":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/media?parent=258340"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/categories?post=258340"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/tags?post=258340"},{"taxonomy":"location","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/location?post=258340"},{"taxonomy":"article_type","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/article_type?post=258340"},{"taxonomy":"serie","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/serie?post=258340"},{"taxonomy":"archives","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/archives?post=258340"},{"taxonomy":"internal_archives","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/internal_archives?post=258340"},{"taxonomy":"reboot-archive","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/reboot-archive?post=258340"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}