{"id":170557,"date":"2019-04-30T12:55:09","date_gmt":"2019-04-30T10:55:09","guid":{"rendered":"https:\/\/innovationorigins.com\/?p=170557"},"modified":"2019-04-30T12:55:09","modified_gmt":"2019-04-30T10:55:09","slug":"immune-system-hygiene-childhood","status":"publish","type":"post","link":"https:\/\/ioplus.nl\/archive\/en\/immune-system-hygiene-childhood\/","title":{"rendered":"Too much hygiene in childhood is bad for the immune system"},"content":{"rendered":"

Researchers at the Universities of Zurich (UZH<\/a>) and Lausanne (UNIL<\/a>) have now scientifically proven in a study what many people have been suspecting for a long time: We are not doing our children any favors by shielding them from everything, especially anything that might make them ill. The human immune system forms by “training” during childhood.<\/p>\n

The so-called hygiene hypothesis provides a widely regarded perspective. According to this hypothesis, improved hygiene, changes in agriculture and urbanization are to blame for the fact that our immune system comes into contact with certain microbes less often or later in life than before, making us more susceptible to diseases. This would increase chronic inflammatory diseases, allergies, and mental disorders such as depression.<\/p>\n

\"Immunsystem\"
\u00a9 Curology on Unsplash<\/figcaption><\/figure>\n

But not only too much hygiene, but also traumas experienced in childhood and allergies could trigger chronic inflammatory diseases and psychological impairments in adulthood. The Swiss scientists were able to prove these assumptions by identifying the early immune system programming of five groups of people.<\/p>\n

One in five people has a very resistant immune system<\/h3>\n

The researchers based their study on the hygiene hypothesis and analyzed the epidemiological data of almost 5,000 people born in the mid-20th century. They concentrated on the coincidence of allergies, viral and bacterial diseases, and psychosocial stress in childhood. The scientists identified five different groups that they characterized by biomarkers (white blood cell counts, inflammatory markers). In a further step, they associated them with chronic inflammatory diseases and psychological disorders during adulthood.<\/p>\n

The results showed that 60 percent of the individuals examined had an ordinary, “neutral” immune system and that their disease burden in childhood was comparatively low. 20 percent of the cohort exhibited a particularly resistant, “resilient” immune system. “Even symptoms of common childhood diseases like measles, mumps or rubella, which were not preventable in the mid-20th century, appeared far less frequently in this group than in the \u201cneutral\u201d group,” the researchers write.<\/p>\n

On the other hand, there were also three smaller groups: 7% of the individuals, the “atopic” group, showed multiple allergic diseases. The “mixed” group (around 9%) had single allergic disorders. They suffered, for example, from drug allergies, bacterial and rash-inducing childhood diseases like scarlet fever, pertussis or rubella. The smallest of the five groups (around 5%) consisted of people who were traumatized in childhood. These people were more susceptible to allergic disease but were relatively resistant to typical viral childhood viral diseases.<\/p>\n

\"Immunsystem\"
\u00a9 Pixabay<\/figcaption><\/figure>\n

Hygiene hypothesis confirmed<\/h3>\n

An interesting and important point of the study is that the neutral and resilient groups are larger among people with earlier birth years than they were among individuals with later birth years. In contrast, the \u201catopic\u201d group, i.e. those people who are more likely to show hypersensitivity reactions, has increased among younger cohorts. \u201cOur study thus corroborates the hygiene hypothesis,\u201d lead author Vladeta Ajdacic-Gross from the University of Zurich says, \u201cbut at the same time goes beyond it.\u201d<\/p>\n

Differences between the groups would manifest themselves also in later health. People of the \u201cresilient\u201d group were not only better protected against chronic inflammatory diseases in adulthood, but also against mental disorders. Members of the \u201catopic\u201d and \u201cmixed\u201d group had an increased risk of disease as adults, both physically and mentally. In the \u201ctraumatized\u201d group, people were more susceptible to mental illnesses in adulthood, and the women also had a higher risk of chronic inflammatory diseases.<\/p>\n

\u201cThe findings of the study indicate that the human immune system acts like a switchboard between somatic and psychic processes,\u201d Ajdacic-Gross explains. \u201cThey help us understand why many people who do not have a history of psychosocial trauma get afflicted by mental disorders and, conversely, why traumatized people show a predisposition to chronic inflammatory diseases.\u201d<\/p>\n

The results of the study “A step beyond the hygiene hypothesis – immune-mediated classes determinded in a population-based study” were published in the online journal BMC Medicine<\/em><\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Researchers at the Universities of Zurich (UZH) and Lausanne (UNIL) have now scientifically proven in a study what many people have been suspecting for a long time: We are not doing our children any favors by shielding them from everything, especially anything that might make them ill. The human immune system forms by “training” during […]<\/p>\n","protected":false},"author":1660,"featured_media":508855,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[42],"tags":[34155,34157,34159,34161],"location":[24456],"article_type":[],"serie":[],"archives":[],"internal_archives":[],"reboot-archive":[],"class_list":["post-170557","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sustainability-nl","tag-hygiene-en","tag-immune-system","tag-university-of-lausanne","tag-university-of-zurich","location-germany"],"blocksy_meta":[],"acf":{"subtitle":"","text_display_homepage":false},"author_meta":{"display_name":"Petra Wiesmayer","author_link":"https:\/\/ioplus.nl\/archive\/author\/petra-wiesmayer\/"},"featured_img":"https:\/\/ioplus.nl\/archive\/wp-content\/uploads\/2019\/04\/curology-1540892-unsplash.jpg","coauthors":[],"tax_additional":{"categories":{"linked":["Sustainability<\/a>"],"unlinked":["Sustainability<\/span>"]},"tags":{"linked":["Hygiene<\/a>","immune system<\/a>","University of Lausanne<\/a>","University of Zurich<\/a>"],"unlinked":["Hygiene<\/span>","immune system<\/span>","University of Lausanne<\/span>","University of Zurich<\/span>"]}},"comment_count":"0","relative_dates":{"created":"Posted 7 years ago","modified":"Updated 7 years ago"},"absolute_dates":{"created":"Posted on April 30, 2019","modified":"Updated on April 30, 2019"},"absolute_dates_time":{"created":"Posted on April 30, 2019 12:55 pm","modified":"Updated on April 30, 2019 12:55 pm"},"featured_img_caption":"","series_order":"","_links":{"self":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/posts\/170557","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/users\/1660"}],"replies":[{"embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/comments?post=170557"}],"version-history":[{"count":0,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/posts\/170557\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/media\/508855"}],"wp:attachment":[{"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/media?parent=170557"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/categories?post=170557"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/tags?post=170557"},{"taxonomy":"location","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/location?post=170557"},{"taxonomy":"article_type","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/article_type?post=170557"},{"taxonomy":"serie","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/serie?post=170557"},{"taxonomy":"archives","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/archives?post=170557"},{"taxonomy":"internal_archives","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/internal_archives?post=170557"},{"taxonomy":"reboot-archive","embeddable":true,"href":"https:\/\/ioplus.nl\/archive\/wp-json\/wp\/v2\/reboot-archive?post=170557"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}